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Tenofovir disoproxil fumarate (10g) (TDF-10g)



SKU: TDF-10g Category:


Tenofovir disoproxil fumarate (tenofovir DF) is a type of anti-HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI).
MDL number MFCD00952920
Cas Number : 201341-05-1
Molecular Weight : 519.4400

Tenofovir disoproxil is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. It may be used for prevention of HIV/AIDS among those at high risk before exposure, and after a needlestick injury or other potential exposure. It is sold both by itself and together as emtricitabine/tenofovir and efavirenz/emtricitabine/tenofovir.


[1] R. Salimi, I. Begum, D.M. Varma, B. Nandakrishna, R. Rajesh, S. Vidyasagar, Tenofovir disoproxil fumarate-induced distal renal tubular acidosis: A case report, Int J STD AIDS 31(3) (2020) 276-279.

[2] W.R. Zhang, R. Scherzer, M.M. Estrella, S.B. Ascher, A. Muiru, V. Jotwani, C. Grunfeld, C.R. Parikh, D. Gustafson, S. Kassaye, A. Sharma, M. Cohen, P.C. Tien, D.K. Ng, F.J. Palella, Jr., M.D. Witt, K. Ho, M.G. Shlipak, Tenofovir disoproxil fumarate initiation and changes in urinary biomarker concentrations among HIV-infected men and women, AIDS 33(4) (2019) 723-733.

[3] S. Noe, S. Heldwein, H. Jaeger, M. Page, E. Wolf, Tenofovir disoproxil fumarate/emtricitabine is associated with a higher risk of hypocalcemia compared to abacavir/lamivudine – results from a German cohort study, Int J STD AIDS 30(5) (2019) 447-452.

[4] M. Lu, H. Dong, D. Bao, B. Liu, H. Liu, Tenofovir disoproxil fumarate induces pheochromocytoma cells apoptosis, Eur J Pharmacol 844 (2019) 139-144.

[5] K. Liu, J. Choi, A. Le, T.C. Yip, V.W. Wong, S.L. Chan, H.L. Chan, M.H. Nguyen, Y.S. Lim, G.L. Wong, Tenofovir disoproxil fumarate reduces hepatocellular carcinoma, decompensation and death in chronic hepatitis B patients with cirrhosis, Aliment Pharmacol Ther 50(9) (2019) 1037-1048.

[6] M.J. Keller, L. Wood, J.M. Billingsley, L.L. Ray, J. Goymer, S. Sinclair, A.P. McGinn, M.A. Marzinke, B. Frank, S. Srinivasan, C. Liu, J.M. Atrio, L. Espinoza, N. Mugo, H.M.L. Spiegel, P.L. Anderson, D.N. Fredricks, C.W. Hendrix, J. Marrazzo, S.E. Bosinger, B.C. Herold, Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial, Lancet HIV 6(8) (2019) e498-e508.

[7] S. Kaneko, M. Kurosaki, N. Tamaki, J. Itakura, T. Hayashi, S. Kirino, L. Osawa, K. Watakabe, M. Okada, W. Wang, T. Shimizu, M. Higuchi, K. Takaura, Y. Yasui, K. Tsuchiya, H. Nakanishi, Y. Takahashi, M. Watanabe, N. Izumi, Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate, J Gastroenterol Hepatol 34(11) (2019) 2004-2010.

[8] R. Guner, Z. Kocak Tufan, G.R. Yilmaz, A.T. Mehmet, Tenofovir disoproxil fumarate may not cause renal and bone toxicity in chronic hepatitis B patients: a retrospective cross-sectional study, Turk J Med Sci 49(1) (2019) 451-452.

[9] J.A. Fields, M.K. Swinton, A. Carson, B. Soontornniyomkij, C. Lindsay, M.M. Han, K. Frizzi, S. Sambhwani, A. Murphy, C.L. Achim, R.J. Ellis, N.A. Calcutt, Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice, Sci Rep 9(1) (2019) 17158.

[10] J. Cusato, A. Calcagno, A. De Nicolo, K. Mogyorosi, A. D’Avolio, G. Di Perri, S. Bonora, Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2, Diagn Microbiol Infect Dis 94(2) (2019) 202-204.

[11] A. Calcagno, M. Fiumano, D. Zugna, J. Cusato, C. Montrucchio, L. Marinaro, L. Trentini, M. Ferrara, A. D’Avolio, C. Pizzi, G. Di Perri, S. Bonora, Tenofovir disoproxil fumarate discontinuation for renal outcomes: any room for treatment personalization?, Pharmacogenomics J 19(1) (2019) 65-71.

[12] P. Zhang, Q. Liu, M. Yuan, L. Wang, Tenofovir disoproxil fumarate reduce incidence of HCC development in CHB-patients with compensated cirrhosis, Infect Agent Cancer 13 (2018) 30.

[13] R.R. Patel, R. Presti, L.C. Harrison, W.G. Powderly, P.A. Chan, Tenofovir disoproxil fumarate as pre-exposure prophylaxis for HIV prevention in women with osteoporosis: a case report and review of the literature, Antivir Ther 23(4) (2018) 379-382.

[14] S. Noe, S. Heldwein, C. Wiese, R. Pascucci, A. von Krosigk, F. Schabaz, C. Jonsson-Oldenbuettel, H. Jaeger, E. Wolf, Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort, Adv Pharmacol Sci 2018 (2018) 6069131.

[15] D. Mizushima, D.T.H. Nguyen, D.T. Nguyen, S. Matsumoto, J. Tanuma, H. Gatanaga, N.V. Trung, N. van Kinh, S. Oka, Tenofovir disoproxil fumarate co-administered with lopinavir/ritonavir is strongly associated with tubular damage and chronic kidney disease, J Infect Chemother 24(7) (2018) 549-554.

[16] S.H. Lee, G.J. Cheon, H.S. Kim, S.G. Kim, Y.S. Kim, S.W. Jeong, J.Y. Jang, B.S. Kim, B.G. Jun, Y. Don Kim, D.W. Jun, J.H. Sohn, T.Y. Kim, B.S. Lee, Tenofovir disoproxil fumarate monotherapy is superior to entecavir-adefovir combination therapy in patients with suboptimal response to lamivudine-adefovir therapy for nucleoside-resistant HBV: a 96-week prospective multicentre trial, Antivir Ther 23(3) (2018) 219-227.

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[18] M.K. Kang, J.G. Park, Tenofovir disoproxil fumarate-induced severe liver injury in a patient with chronic hepatitis B virus infection, Dig Liver Dis 50(6) (2018) 628-630.

[19] A. Hill, S.L. Hughes, D. Gotham, A.L. Pozniak, Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in efficacy and safety?, J Virus Erad 4(2) (2018) 72-79.

[20] P.L. Havens, D. Long, G.U. Schuster, C.M. Gordon, G. Price, C.M. Wilson, B.G. Kapogiannis, K. Mulligan, C.B. Stephensen, H.I.V.A.I. Adolescent Medicine Trials Network for, t. study, Tenofovir disoproxil fumarate appears to disrupt the relationship of vitamin D and parathyroid hormone, Antivir Ther 23(7) (2018) 623-628.

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[22] W. Tun-Yhong, C. Chinpaisal, P. Pamonsinlapatham, S. Kaewkitichai, Tenofovir Disoproxil Fumarate Is a New Substrate of ATP-Binding Cassette Subfamily C Member 11, Antimicrob Agents Chemother 61(4) (2017).

[23] H. Shen, W. Li, W.G. Humphreys, Y. Lai, Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1, J Pharmacol Exp Ther 360(2) (2017) 341-342.

[24] J. Shailender, P.R. Ravi, P. Saha, A. Dalvi, S. Myneni, Tenofovir disoproxil fumarate loaded PLGA nanoparticles for enhanced oral absorption: Effect of experimental variables and in vitro, ex vivo and in vivo evaluation, Colloids Surf B Biointerfaces 158 (2017) 610-619.

[25] A.A. Shaheen, M. AlMattooq, S. Yazdanfar, K.W. Burak, M.G. Swain, S.E. Congly, M.A. Borman, S.S. Lee, R.P. Myers, C.S. Coffin, Tenofovir disoproxil fumarate significantly decreases serum lipoprotein levels compared with entecavir nucleos(t)ide analogue therapy in chronic hepatitis B carriers, Aliment Pharmacol Ther 46(6) (2017) 599-604.

[26] R. Samuels, C.R. Bayerri, J.A. Sayer, D.A. Price, B.A.I. Payne, Tenofovir disoproxil fumarate-associated renal tubular dysfunction: noninvasive assessment of mitochondrial injury, AIDS 31(9) (2017) 1297-1301.

[27] F.A. Post, L. Hamzah, J. Fox, Tenofovir disoproxil fumarate-associated bone loss: does vitamin D-binding protein play a role?, AIDS 31(1) (2017) 178-179.

[28] L.M. Mofenson, R.C. Baggaley, I. Mameletzis, Tenofovir disoproxil fumarate safety for women and their infants during pregnancy and breastfeeding, AIDS 31(2) (2017) 213-232.

[29] S. Khan, C.A. Funk, K. Corado, S. Morris, M.P. Dube, Tenofovir Disoproxil Fumarate-Associated Fanconi Syndrome in an Human Immunodeficiency Virus (HIV)-Uninfected Man Receiving HIV Pre-Exposure Prophylaxis, Open Forum Infect Dis 4(3) (2017) ofx149.

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[31] Y.C. Hsu, M.T. Wei, M.H. Nguyen, Tenofovir alafenamide as compared to tenofovir disoproxil fumarate in the management of chronic hepatitis B with recent trends in patient demographics, Expert Rev Gastroenterol Hepatol 11(11) (2017) 999-1008.

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[37] C.Y. Cheng, S.Y. Chang, M.H. Lin, S.Y. Ku, N.L. Sun, S.H. Cheng, Tenofovir disoproxil fumarate-associated hypophosphatemia as determined by fractional excretion of filtered phosphate in HIV-infected patients, J Infect Chemother 22(11) (2016) 744-747.

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[40] D.H. Yang, Y.J. Xie, N.F. Zhao, H.Y. Pan, M.W. Li, H.J. Huang, Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients, World J Gastroenterol 21(9) (2015) 2746-53.

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