CellPhilic™ Trehalose dihydrate; (Purity >99%)
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Trehalose dihydrate; (Purity >99%)
CAS No: 6138-23-4
MDL No: MFCD00071594
EC Number 202-739-6
Chemical Formula: C12H22O11·2H2O
Molecular Weight: 378.33
Synonym: α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
Appearance: White crystalline powder
Solubility H2O: 50 mg/mL
D-(+)-Trehalose dihydrate is a non-reducing disaccharide. It is used to protect enzymes, vaccines, cells and many other molecules. It has been used in a slow-freezing method for freezing rabbit oocytes. It has also been used in solid-surface vitrification (SSV) of in vitro-matured oocytes.
Trehalose is essential for embryogenesis, carbon metabolism, photosynthesis and flowering in plants. It predominantly exists among the species that supports anhydrobiosis (life without water). It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions, such as heat, cold, dehydration, desiccation and oxidation. Trehalose acts as a chemical chaperone affecting protein folding. It is known to prevent amyloid generation and accummulation of β-amyloid in vitro. A similar effect of trehalose has been observed with huntingtin protein aggregation. Thus, it might serve as a protective agent in Alzheimer′s disease and Huntington′s disease.
Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.