2-Deoxy-D-glucose (2-DG), >98% (5g)
2-Deoxy-D-glucose (2-DG, 2DG), >98% (5g)
PURITY LIMIT:≥ 98% (HPLC Assay)
MOLECULAR FORMULA: C6H12O5
MDL NO: MFCD00151328
APPEARANCE: White to almost white powder
OPTICAL ROTATION: +45.0° to +47.5°
STORAGE TEMP:Store at Room Temperature. It is fine to freeze.
solubility water: 5 mg/mL
2-Deoxy-D-glucose (2-DG) is a non-metabolizable derivative of glucose that can be carried by the glucose carrier in human cells. 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. Reported to reduce the incidence of doxorubicin-induced apoptosis. 2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
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