Zoledronate (100 mg)

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Zoledronate (100 mg)
Catalog #: ZO-100mg
Purity: ≥98% (HPLC)
Synonym: Zoledronic acid anhydrous, P,P’-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic Acid; [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid; (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene-1,1-bisphosphonic acid; 2-(Imidazol-1-yl)-1-hydroxy-1,1’-ethylidenediphosphonic acid; Aclasta; BPH 91; CGP 42446; Orazol; Reclast; ZOL 446; Zometa
CAS Number: 118072-93-8
Purity:≥98%
Molecular Weight: 272.09
Molecular Formula: C5H10N2O7P2
PubChem ID: 68740
InChI Key: XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles: OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1
Appearance: White to Off-White Solid
Melting Point: >210°C (Subl.)
Solubility: Soluble in DMSO (0.004 mg/ml at 25° C), water (Max Conc. 0.68mg/mL, 2.5mM), and ethanol (<1 mg/ml at 25° C). Storage: Store at -20° C

Description

Description

A protein kinase C activator with apoptotic effects
Zoledronic acid is potent farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM) and one of the most potent nitrogen-containing bisphosphonates. It prevents the isoprenylation of small GTP-binding proteins such as Ras and Rho.
Zoledronate attenuates accumulation of DNA damage in stem cells and protects their function [1]. Suggested final concentration in culture medium is 1uM.
Zoledronate affecting conditions arising from stem-cell dysfunction makes it a promising medicine for a range of age-related diseases[2].

[1] Juhi Misra, Sindhu T. Mohanty, Sanjeev Madan, James A. Fernandes, F. Hal Ebetino, R. Graham, G. Russell, Ilaria Bellantuono. (December 2015). Zoledronate attenuates accumulation of DNA damage in mesenchymal stem cells and protects their function. Stem Cells, doi:10.1002/stem.2255
[2] “Bone drug protects stem cells from aging.” ScienceDaily. 17 December 2015