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Zoledronic acid monohydrate (1 g)



Zoledronic acid monohydrate (1g)
Catalog #: ZOH-1g
Purity: ≥98% (HPLC)
Synonym: P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate, Zoledronate monohydrate, [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
CAS Number: 165800-06-6
Chemical Formula: C5H10N2O7P2·H2O
Molecular Weight: 290.10
Appearance: White to off-white crystalline powder
Purity (HPLC): ≥98.5%
MDL number: MFCD08448695
PubChem Substance ID: 329825242
Storage: Store at -20° C



A protein kinase C activator with apoptotic effects
Zoledronic acid is potent farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM) and one of the most potent nitrogen-containing bisphosphonates. It prevents the isoprenylation of small GTP-binding proteins such as Ras and Rho.
Zoledronate attenuates accumulation of DNA damage in stem cells and protects their function [1]. Suggested final concentration in culture medium is 1uM.
Zoledronate affecting conditions arising from stem-cell dysfunction makes it a promising medicine for a range of age-related diseases[2].

[1] Juhi Misra, Sindhu T. Mohanty, Sanjeev Madan, James A. Fernandes, F. Hal Ebetino, R. Graham, G. Russell, Ilaria Bellantuono. (December 2015). Zoledronate attenuates accumulation of DNA damage in mesenchymal stem cells and protects their function. Stem Cells, doi:10.1002/stem.2255
[2] “Bone drug protects stem cells from aging.” ScienceDaily. 17 December 2015