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HCTU (25g; HCTU25)


HBTU (25g)
Catalog # HBTU25
Synonym: N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate, O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate
≥ 99% (HPLC)
CAS Number 94790-37-1
Empirical Formula (Hill Notation) C11H16F6N5OP
Molecular Weight 379.24
Beilstein Registry Number 7328329
EC Number 423-020-5
MDL number MFCD00075445
PubChem Substance ID 57647025

HBTU is a peptide coupling agent for peptide synthesis. It has been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol. Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields.

SKU: HCTU25 Category:


HCTU (25g)
Catalog # HCTU25
Synonym: O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide hexafluorophosphate, N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium hexafluorophosphate
CAS Number: 330645-87-9
Empirical Formula (Hill Notation) C11H15ClF6N5OP
Molecular Weight 413.69
MDL number MFCD04973268
PubChem Substance ID 329747994
Purity Limit ≥ 98% (HPLC)
Appearance White to off-white crystalline powder
Melting Point 178 – 193 ºC
Warnings: Light sensitive
Storage Temp: 0-8 °C

HCTU is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides, in hindered couplings, and cyclizations. It can also be used for Tandem Oligonucleotide Synthesis on Solid-Phase Supports for the Production of Multiple Oligonucleotides.

Reagent for:
Synthesis of near-infrared pH activatable fluorescent probes.
Synthesis of human β-amyloid by Fmoc chemistry.
Stereoselective Horner-Wadsworth-Emmons olefination.
Covalent ligation of fluorescent peptides to quantum dots.
Alkylation of human telomere sequence.